It's bad enough when your box art looks like you came directly from the bargain bin, but it's even worse when said box art is hiding what's actually a good game. Dead Space: Extraction was a great use of the "Guided Experience" mechanic, and told a tightly-wound story that worked with what the tech that the developers use; that's what makes the game's box art that much more of a crime. There have been worse box arts this year, but most of them deserve the awful photoshop graphics and extreme text on the cover. Extraction had it hard enough as it is, and I'm sure this atrocious box art only made things worse.
Runners-Up: Jurassic: The Hunted, Deadly Creatures